A teenage girl's wilderness hike with friends spirals after they stumble upon a crashed drug plane, forcing her to outwit a ruthless gang and face an enemy far worse than drug smugglers.

Based on graphic novel by Jeff Lemire. Four disparate characters linked together through bloodlines. The lead characters ebb and flow into each other's lives, slowly weaving connections between them that ultimately save and redeem them.

While travelling on their first American tour, Ms. 45, an all-girl punk band, is drugged and kidnapped. They awaken to find their limbs removed and replaced with crude weaponry, and are forced to fight as Gladiators for a sadistic town.